![]() ![]() H.The interval from calving to initiation of superovulation treatment should be at least 3 months. G.The effect of repeated treatments with PLUSET over long periods has not been assessed for all possible schedule treatment Therefore it is recommended that PLUSET not be administered more than twice for superovulation and that at least one natural oestrus cycle be allowed to occur between the two superovulation treatments. Breeding can take place at the first heat after superovulation, which normally is seen after 28 days. Following the non-surgical recovery of embryos on day 7, it is recommended to give the animals another prostaglandin treatment to assure a rapid return to heat if not, animals should be examined 4 weeks after, to ascertain that normal ovarian activity has been restored. A luteolytic dose of prostaglandin F 2 alpha or analogue should be given intramuscularly at 60 and/or 72 hours after the beginning of superovulation treatment.Į.Standing oestrus will take place 40-48 h after prostaglandin treatment and animals should be bred 12 h after the onset of standing heat and, again 12 h later with high quality semen.į. Ovarian examination should confirm the presence of a functional corpus luteum and the absence of any pathological conditions such as cystic ovarian degeneration or adhesions around the ovaries.Ĭ.Treatment should be initiated between day 9 and 12 of the oestrous cycle (with day 11 generally giving best results).ĭ. The following recommendations for the use of PLUSET for the induction of superovulation with adequate response should be followed:Ī.The donor animal must have had at least one normal oestrous cycle prior to the initiation of PLUSET treatment.ī.The donor animal should not have any signs of clinical illness when treatment with PLUSET begins. To induce superovulation in reproductively mature heifers or cows. Kinetic studies of FSH and LH in the bloodstream of bovine has shown a half-life of 150 minutes for FSH and a half-life of 40 minutes for LH. PLUSET is manufactured in a method chosen to ensure that the defined level of LH content is consistently mantained. Thus, given that it influences the activity of FSH, it is important to have a defined level of LH present. The pituitary hormone extract contains variable levels of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).Ĭlearly in order to obtain proper and effective superovulation which provides satisfactory results involving a high number of living embryos, it is necessary to carry out a treatment that guarantees the activation and progress of multiple follicle maturation in the most “physiological” and repeatable way possible. Ovarian stimulation with exogenous Follicle-Stimulating Hormone (FSH) allows a greater number of ova to be produced than normally produced in a single reproductive cycle. In the absence of an International Standard for the porcine gonadotrophin, dosing is carried out using the International Standard for human urine FSH and LH. The use of standardized concentrations for both gonadotrophins guarantees a consistent quality of the product and eliminates possible variability in effectiveness from one lot to another. PLUSET is a mixture of swine pituitary gonadotrophins used for the induction of multiple ovulations (superovulation). For further information about unapproved drugs, click here. of Labor Section 503 standards for federal contractors.PLUSET- porcine follicle stimulating hormone, porcine luteinizing hormoneĭisclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. Accommodating and affirming workforce diversity.Lower rate of employee turnover – average placement is 5 years.Job coach services on-site at your business.Assure consistent employee work performance and attendance.Save time and money in the selection and training of new employees.Currently more than 150 businesses in Dane County and Sauk employ individuals supported by MARC. MARC services are funded by public sources and we work toward meaningful and effective employment relationships. To assure a successful employment relationship with the person who has a disability, MARC provides all the: ![]() MARC has over 65 years of experience working with high school students and adults with developmental disabilities to find employment in Dane County and Sauk businesses. ![]()
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